Los Blancos saw their seven match unbeaten La Liga away run come to an end a little under two weeks ago with a 2-1 loss at Valencia.
Madrid have since responded with a 2-1 comeback win against Eibar on home soil, and now they have the chance to close the gap on leaders Barcelona to a slightly more respectable 11 points with victory over fellow Madrilean opposition.
Madrid are expected to be without captain Ramos for the next couple of weeks because of a calf injury sustained in training earlier this week, so Raphael Varane and Nacho should start together once again.
Dani Carvajal is back available for selection after more than a month on the sidelines, but Zidane may decide to stick with Alvaro Odriozola down the right. On the opposite flank, it is a straight choice between Marcelo and Sergio Reguilon.
Zidane used Federico Valverde in the holding midfield position against Eibar, but Casemiro seems certain to return on Monday, while Toni Kroos - a second-half sub in that match - is also pushing for inclusion.
Karim Benzema has been a regular under Zidane, meanwhile, scoring two more goals last week to maintain his record of being directly involved in at least one goal in each of his last five outings.
Elsewhere, Courtois is still nursing a thigh injury and is unlikely to return for at least another week.