Ronaldo is currently at the Confederations Cup with Portugal, and Santos is confident that the 32-year-old's full focus is on helping his country to success rather than his individual situation.
"I tell you that tomorrow we have a very important game. All the players are concentrated and Cristiano Ronaldo is extremely concentrated with the Russian game tomorrow, which we will play," he told reporters.
"There are no easy games, all national team games are difficult. There are no easy opponents, all games are complicated, so I expect my team to bring home the bacon at the right time.
"Don't forget that most of these players here were part of the most brilliant history in Portuguese history just a year ago [at the European Championships], we should not forget that and so I trust them 100%."
Ronaldo, who has been linked with world-record moves to Manchester United and Paris Saint-Germain, will feature when Portugal take on Confederations Cup hosts Russia in Moscow on Wednesday.