McGoldrick replaces summer signing Balint Bajner up front after netting on the opening day of the season.
Adkins also names an all-academy bench, which has an average age of just 19.
The Royals have won five of the previous six meetings between the clubs, losing one.
Reading: Federici; Gunter, Cummings, Hector, Pearce; Obita, Akpan, Taylor, Cox; Blackman, Pogrebnyak
Subs: McCarthy, Cooper, Kuhl, Tshibola, Edwards, Stacey, Tanner
Ipswich Town: Gerken; Mings, Chambers, Smith, Berra; Skuse, Murphy, McGoldrick, Tabb, Hyam, Hewitt
Subs: Bialkowski, Parr, Anderson, Bru, Wordsworth, Bajner, Sammon