Despite relinquishing the title to their bitter rivals, Ally McCoist's side would like nothing more than to have the local bragging rights going into the summer.
Similarly, the Hoops can cap a season in which they deservedly picked up the SPL trophy with a victory in the back yard of their perennial enemies.
Georgios Samaras, Scott Brown and Glenn Loovens are all expected to return to the Celtic starting lineup after they were rested in last weekend's win against Motherwell, but Ki Sung-yueng and James Forrest are both sidelined through injury.
Rangers have won two Old Firm encounters this season, while Celtic have triumphed on one occasion.
Celtic: Forster; Mulgrew, Loovens, K Wilson, Izaguirre; Brown, Wanyama, Ledley, Hooper; Stokes; Samaras
Rangers: McGregor; Goian, Wallace, Bocanegra, Bartley, Whittaker; McCulloch, Edu, McCabe, Little; Aluko
Sports Mole says: 2-1