The Portuguese manager made nine changes for the penalty-shootout defeat at Manchester City in the EFL Cup on Tuesday but reverts to the same starting XI that delivered a 3-2 win over Preston North End last weekend as he looks to return to the top of the table following Sheffield United's win at Leeds United last night.
Ivan Cavaleiro, Diogo Jota and Leo Bonatini spearhead the attack in Nuno's favoured 3-4-3 formation, with Matt Doherty and Barry Douglas operating either side of Romain Saiss and Ruben Neves in midfield.
As for the hosting Hoops, Ian Holloway makes three alterations to his starting XI following the 1-1 draw at rock-bottom Bolton Wanderers a week ago.
Pawel Wszolek drops to the bench and Ryan Manning misses out as Jordan Cousins - making his first appearance of the season after a hamstring injury - links up with Josh Scowen and Massimo Luongo in the middle of the park.
Queens Park Rangers: Smithies; Baptiste, Lynch, Bidwell, Robinson; Scowen, Luongo, Cousins; Freeman, Washington, Sylla
Subs: Lumley, Furlong, Wszolek, Ngbakoto, Wheeler, Mackie, Smith
Wolverhampton Wanderers: Ruddy; Batth, Coady, Miranda; Doherty, Saiss, Neves, Douglas; Cavaleiro, Bonatini, Jota
Subs: Norris, N'Diaye, Bennett, Marshall, Boly, Costa, Enobakhare