The Posh currently sit two points away from safety after 12 games in the season so far, while Derby could move nearer to the playoff places if they are able to secure an away win at London Road.
Both sides head into the meeting on the back of victories but Derby are currently on a five-game unbeaten run and Nigel Clough's men will be hoping to extend that figure this weekend.
Peterborough boss Darren Ferguson is expected to line up with George Boyd up front following his brace in the Posh's 3-1 win over Huddersfield Town, while Derby will be hoping that Theo Robinson can find the back of the net for the visitors.
Peterborough: Olejnik; Alcock, Brisley, Knight-Percival; Little, Bostwick, McCann, Ntlhe, Tomlin; Berahino, Boyd
Derby: Legzdins; Brayford, Buxton, Keogh, O'Connor; Coutts, Bryson, Hughes, Jacobs; Robinson, Sammon
Sports Mole says: 1-1