Penarol vs. Defensa (Tuesday, 11.00pm)
The visitors can book their spot in the playoff round with a victory, and they could also go top of the group, which would put them in a strong position to qualify for the round of 16, while the hosts have already been eliminated from the competition.
We say: Penarol 0-2 Defensa y Justicia
Considering the game means very little to Penarol, and Defensa y Justicia won the reverse fixture by a three-goal margin, we expect the visitors to emerge as comfortable victors on Tuesday evening.
Defensa have looked very solid in recent weeks, losing just one of their last 11 games in all competitions, and they have displayed they have what it takes to book their place in the next round of the Copa Sudamericana.
Estudiantes vs. Fortaleza (Tuesday, 11.00pm)
The winless hosts have been eliminated from the competition, whereas the away side seeks to seal progress as table toppers at Estadio Metropolitano.
We say: Estudiantes Merida 1-3 Fortaleza
With Estudiantes in dire straits, Fortaleza are favourites to make mincemeat of their hosts on Tuesday, with a dominant 3-1 triumph a possibility at Estadio Metropolitano to secure a fifth straight group stage triumph.
Tigre vs. Puerto Cabello (Wednesday, 1.00am)
The hosts are struggling domestically but have a good chance of progressing in continental competition, whist Puerto Cabello are leading the way in Venezuela.
We say: Tigre 4-0 Academia Puerto Cabello
Tigre have a chance of earning their place in the knockout stages of the competition in this one and should be confident of beating a visiting side who have not managed to collect a point yet.
Puerto Cabello will be in damage limitation mode as they look to put this Sudamericana campaign behind them as quickly as possible - it promises to be a difficult evening in Argentina.
America Mineiro vs. Millonarios (Wednesday, 1.00am)
The hosts have already been eliminated from South America's secondary continental competition after picking up just four points from four matches so far.
We say: America Mineiro 1-1 Millonarios
America Mineiro appear to have found better form across their recent outings, but unfortunately it has arrived too late for them to remain in the Copa Sudamericana.
With the hosts likely to rest several key players ahead of an important league game at the weekend, we can envisage a share of the spoils in this match, which may not be enough to keep Millonarios on top of Group F.
Santos vs. Newell's OB (Wednesday, 1.30am)
The visitors, meanwhile, have already secured their progression to the knockout stages, and they could have top spot in Group E confirmed in midweek.
We say: Santos 1-0 Newell's Old Boys
Santos will surely be more motivated to win this match than their opponents, who know that avoiding defeat in their final group game against Audax Italiano will be enough for them to secure first position in Group E.
As such, we expect the hosts to edge a tight encounter, which would ensure that they remain in the competition heading into the final matchday.
LDU Quito vs. Botafogo (Wednesday, 3.00am)
Both sides head into the midweek game knowing they could grab an automatic pass to the knockout stages as they currently sit level on eight points at the top of Group A.
We say: LDU Quito 1-0 Botafogo
With first place in Group A potentially on the line, we anticipate a fierce battle at the Estadio Rodrigo Paz Delgado on Wednesday. LDU are unbeaten in their last eight matches across all competitions, and given Botafogo's contrasting form, we are backing them to come out on top in front of their home supporters.