Rotherham won all three points in a 3-0 win away at Aldershot Town.
Bradford came back from a goal down to beat Cheltenham Town 3-1, while Chesterfield helped themselves to a 1-0 win away at Exeter.
Two goals from Tom Eaves helped Bristol Rovers to secure a 3-2 win over Torquay United in a thrilling game at the Memorial Stadium.
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AFC Wimbledon picked up a point away at Fleetwood Town, while Morecambe took all three points with a 1-0 win over Southend United.
Gillingham performed well in beating Burton Albion 4-1 at home, while Rochdale struggled away at Plymouth Argyle, losing the game 3-1.
Ten-man Wycombe Wanderers succumbed to Port Vale, losing the game 4-1 despite being a goal up at half time.
Two goals from Ashley Chambers helped York City earn all three points in a 3-2 win over Dagenham & Redbridge.
Results in full: Oxford United 5-0 Accrington Stanley, Aldershot Town 0-3 Rotherham, Bradford 3-1 Cheltenham Town, Exeter 0-1 Chesterfield, Bristol Rovers 3-2 Torquay United, Fleetwood Town 1-1 AFC Wimbledon, Morecambe 1-0 Southend United, Gillingham 4-1 Burton Albion, Plymouth Argyle 3-1 Rochdale, Port Vale 4-1 Wycombe Wanderers, York City 3-2 Dagenham & Redbridge.