Monagas vs. Dep. Pereira (Tuesday, 11.00pm)
The visitors are currently second in the section, level on points (seven) with leaders Boca Juniors, while Monagas are bottom, picking up just two points from their opening four matches.
We say: Monagas 0-1 Deportivo Pereira
Deportivo Pereira are in excellent form, winning four of their last five games in all competitions, including a 2-1 success in the reverse game against Monagas. We are expecting Tuesday's affair to be close in terms of the scoreline, but the visitors should have enough quality to secure a huge three points.
Athletico PR vs. Libertad (Tuesday, 11.00pm)
Paulo Turra's side are sitting pretty at the top of Group F with seven points to their name, while their Paraguayan counterparts are only one point worse off in third place.
We say: Athletico Paranaense 2-1 Club Libertad
One month on from Paranaense's slender success on Libertad soil, we can envisage an identical scoreline at the top-left corner of the TV screen this week, as these two sides never seem to have many problems making the net ripple against one another.
The visitors' league defeat at the weekend should not be taken at face value, but with the Hurricane needing no second invitation to assert their dominance at home, Turra's side can put one foot in the knockout stages on Tuesday.
Boca Juniors vs. Colo-Colo (Wednesday, 1.00am)
Boca Juniors and Colo-Colo return to action in the Copa Libertadores when they go head-to-head at the Estadio Alberto J. Armando on Wednesday morning.
Having suffered a 2-0 loss in May's reverse fixture, Gustavo Quinteros's men will head into the midweek clash looking to get one over the hosts and get their campaign back on track.
We say: Boca Juniors 2-0 Colo-Colo
While Colo-Colo will be looking to arrest their slump and get their campaign back on track, they face a formidable side in Boca Juniors, who are on a run of four straight home wins. With that said, we predict the Argentine side will see off the visitors and edge closer to a place in the next phase of the competition.
Alianza Lima vs. Atletico Mineiro (Wednesday, 1.00am)
The Peruvian outfit, who are making their 29th appearance at the continental showpiece, have picked up just one point from their two home games and are currently rooted to the bottom of Group G.
We say: Alianza Lima 1-2 Atletico Mineiro
Buoyed by their victory at the weekend, Atletico Mineiro will head into Wednesday with sky-high morale as they look to make it three wins on the bounce in Group G. Alianza Lima's current form and home record makes Coudet's men favourites and we fancy them picking up all three points.
Melgar vs. Patronato (Wednesday, 1.00am)
Mariano Soso's side are rooted to the bottom of the section with a solitary point to their name, while their visitors occupy third place with three points and can officially end their hosts' continental journey here.
We say: Melgar 1-1 Patronato
Given Patronato's repeated failings in front of goal away from home, there should be no repeat of the 4-1 thumping that they dished out on Melgar last month, especially with the hosts fighting for their lives at the bottom of the section.
Victory may still be out of reach for Sosa's men amid their struggles to convert draws into wins, but a point would be good enough to keep the race for third place alive until the final whistle blows on matchday six, while also extinguishing any slim Patronato hopes of a top-two finish.
Bolivar vs. Cerro Porteno (Wednesday, 3.00am)
With qualification from Group C all but assured, the home side seek a top-place finish against a side still battling for third place in the standings.
We say: Bolivar 2-1 Cerro Porteno
Having claimed maximum points against the stronger sides in Group C, Bolivar should be confident of another victory against struggling Cerro Porteno to make it three wins from three at Estadio Hernando Siles.