Despite the fact that 21 points separate leaders Manchester United and eighth-placed Liverpool, this clash is still one of the most eagerly-anticipated encounters in the Premier League calendar.
While it is not what you would call a local derby, these two clubs share a rivalry based upon trophies and success.
With the two sides due to meet tomorrow afternoon, Sports Mole looks back over five of the most memorable encounters from the Premier League era at Old Trafford.
Man United 2-2 Liverpool - October 18, 1992
Deep into stoppage time though Hughes stooped to meet a cross from Ryan Giggs and he managed to guide the ball beyond the reach Grobbelaar. He then wheeled off to celebrate in front of an empty Stretford End, which was in the process of being rebuilt.
Man United 2-2 Liverpool - October 1, 1995
This is a match that will be etched into the memories of most Man United supporters as it saw the return of Eric Cantona, who had spent the previous eight months suspended for producing the infamous kung-fu kick towards a Crystal Palace fan.
However, with 20 minutes remaining Cantona ensured a share of the spoils for United when he rolled home a penalty after Giggs had been brought down by Jamie Redknapp.
Man United 2-1 Liverpool - January 24, 1999
Granted this was not a league fixture, but this FA Cup tie produced one of the most memorable endings to a clash between these two great rivals.
Michael Owen, who later went on to play for United, headed Liverpool in front with just over two minutes on the clock.
The home team then proceeded to lay siege to the Liverpool goal, but an inspired David James between the posts appeared to have booked the away team's place in round five of the competition.
United, as so often during that season, were not done though and with two minutes left Dwight Yorke turned the ball into the net following a header across goal from strike partner Andy Cole.
Then, just as Liverpool were getting their head around the fact that they would be playing a replay at Anfield, Ole Gunnar Solskjaer came off the bench to beat a wrong-footed James three minutes into stoppage time.
Man United 1-4 Liverpool - March 14, 2009
Heading into this one, Liverpool knew that a defeat would all but end their chances of winning a 19th league title.
What followed was an inspired performance from Rafael Benitez's side and arguably one of the best displays during the Spaniard's era on Merseyside.
All appeared to be going well for the Red Devils when Cristiano Ronaldo put them in front from the penalty spot after Pepe Reina had fouled Park Ji-Sung inside the area.
It would be Liverpool that took the lead going into half-time though thanks to Fernando Torres and a penalty from Steven Gerrard.
Any hope United had of getting back into encounter evaporated ended when Nemanja Vidic was handed his marching orders for hauling down Torres and Fabio Aurelio curled in the resultant free kick.
To rub further salt in the United wound, Andrea Dossena lobbed in a fourth for Liverpool deep into stoppage time.
Man United 2-1 Liverpool - February 11, 2012
There will not be many football fans that forget the main talking point of this encounter.
During the pre-match handshakes, Liverpool striker Luis Suarez refused to shake hands with Man United's Patrice Evra. Those two had previous after Suarez had been banned for eight matches for racially abusing the French defender.
On the pitch Wayne Rooney scored twice shortly after the restart to put United in command.
Suarez found the back of the net late in the encounter, but United held out to claim the bragging rights.