Brighton vs. Swansea (Wednesday, 7.30pm)
While the Seagulls sit in the top four of English football's first tier, Swansea are currently down in 21st place in the Championship.
We say: Brighton & Hove Albion 3-1 Swansea City
Despite the likelihood of changes being made for this contest, we still expect Brighton to come through this fixture. Swansea have the potential to cause a surprise, but competition for places should inspire a strong Seagulls performance.
Man Utd vs. West Ham (Wednesday, 7.45pm)
Ole Gunnar Solskjaer's men claimed a 2-1 win over the Hammers in the capital on Sunday, with none other than Jesse Lingard scoring the all-important winner.
We say: Manchester United 2-2 West Ham United (Man United to win on penalties)
Man United and West Ham both have bigger fish to fry in the coming weeks, but the visitors will certainly be spurred on by the thought of revenge after Sunday's dramatic defeat.
With fringe players on both sides seeking to stake their claims for regular starting roles, we can envisage an entertaining affair at Old Trafford, with the hosts relying on their penalty prowess to book their spot in round four.
Chelsea vs. Aston Villa (Wednesday, 7.45pm)
The visitors have already been through a round of the competition, thrashing fourth-tier Barrow 6-0 in August, while both sides come in on the back of 3-0 victories in the Premier League.
We say: Chelsea 2-0 Aston Villa
Tuchel has developed a well-oiled machine at Stamford Bridge, and they will certainly not want to see their momentum slowed with a cup defeat.
Even if they rest several key players, the Blues still boast more than enough quality to come out of Wednesday's clash unscathed and progress to the next round.
Arsenal vs. AFC Wimbledon (Wednesday, 7.45pm)
The Gunners trounced West Bromwich Albion 6-0 in the second round to advance, while Wimbledon have overcome Charlton Athletic and Northampton Town to get this far.
We say: Arsenal 4-0 AFC Wimbledon
Arsenal are long-overdue a run in the EFL Cup, and one can only begin to imagine what a shock defeat here would mean for Arteta's future in the hotseat.
Wimbledon have looked bright on the attacking front during the early stages of this season, but we still expect a second-string Arsenal XI to cruise through to the next round.
Millwall vs. Leicester (Wednesday, 7.45pm)
The Foxes currently occupy 12th position in the Premier League standings, while Millwall are down in 18th place in the Championship.
We say: Millwall 1-2 Leicester City
Both teams will change things up, something which should lead to an entertaining encounter at The Den. Nevertheless, the Foxes players who feature on Wednesday know that there are spaces available in the first team, and that could lead to a narrow win for the visitors.
Wolves vs. Spurs (Wednesday, 7.45pm)
We say: Wolverhampton Wanderers 1-1 Tottenham Hotspur (Wolves to win on penalties)
Neither Spurs nor Wolves enter this encounter in inspired form, although the visitors can take confidence from their strong record at Molineux and the hosts' goalscoring woes in front of their own fans.
However, we simply cannot separate the two sides on this occasion and expect the tie to be decided from 12 yards, where Wolves could give their fans something to cheer as they knock their former manager out of the tournament.