Atalanta BC face an uphill battle to qualify for the knockout stages of the Champions League after losing each of their first three group stage games in the competition.
The Serie A outfit next host reigning Premier League champions Manchester City, who have lost just twice all season.
Atalanta qualified for the Champions League for the first time in their history last season in swashbuckling style, finishing third in Serie A ahead of both Milan and Rome-based clubs.
Gian Piero Gasperini's side also ended the campaign as the division's top scorers, ahead of eventual champions Juventus and nearest challengers Napoli, netting 77 times in total.
City have bounced back from their 2-0 home defeat to Wolverhampton Wanderers that saw them slip further behind Liverpool in this season's Premier League title race, winning their subsequent five on the trot in all competitions.
City have a perfect record in Europe so far this term, winning each of their three Champions League games to surge to the top of their group.
Guardiola's side could open up a seven-point gap at the top of the group and confirm their qualification to the knockout stages as group winners if they beat Atalanta and Shakhtar Donetsk and Dinamo Zagreb draw with each other.
Atalanta form: DLWDL
Manchester City form: LWWWWW
Pep Guardiola has several names unavailable to him as he prepares to bring his squad to Italy.
David Silva is also a major doubt, leaving Guardiola light on central midfield options at present.
For Atalanta, striker Duvan Zapata is unavailable as he recovers from a muscle injury, but Giamperini has an otherwise fully-fit squad to choose from.
Atalanta possible starting lineup:
Gollini; Toloi, Palomino, Djimsiti; Castagne, Freuler, Pasalic, Gosens; Gomez; Ilicic, Muriel
Manchester City possible starting lineup:
Ederson; Walker, Stones, Otamendi, Angelino; Fernandinho, Gundogan, De Bruyne; B. Silva, Aguero, Sterling
We say: Atalanta 1-3 Manchester City
Atalanta are a fine side, but their Champions League form has been woeful thus far and City will expect to pick them apart just as they did in their last meeting. Raheem Sterling will be licking his lips after his hat-trick against these opponents previously.