The Argentinian frontman pulled up with a groin problem on the half-hour mark and was replaced by Samir Nasri.
The 23-year-old headed straight down the tunnel to receive treatment on the injury.
Since completing his move to the Etihad Stadium during the summer, Aguero has scored eight league goals for the club.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 15 | 11 | 3 | 1 | 31 | 13 | 18 | 36 |
| 2 | Chelsea | 15 | 9 | 4 | 2 | 35 | 18 | 17 | 31 |
| 3 | Arsenal | 16 | 8 | 6 | 2 | 29 | 15 | 14 | 30 |
| 4 | Nottingham ForestNott'm Forest | 16 | 8 | 4 | 4 | 21 | 19 | 2 | 28 |
| 5 | Manchester CityMan City | 15 | 8 | 3 | 4 | 27 | 21 | 6 | 27 |
| 6 | Aston Villa | 16 | 7 | 4 | 5 | 24 | 25 | -1 | 25 |
| 7 | Brighton & Hove AlbionBrighton | 15 | 6 | 6 | 3 | 25 | 22 | 3 | 24 |
| 8 | Bournemouth | 15 | 7 | 3 | 5 | 23 | 20 | 3 | 24 |
| 9 | Fulham | 16 | 6 | 6 | 4 | 24 | 22 | 2 | 24 |
| 10 | Brentford | 15 | 7 | 2 | 6 | 31 | 28 | 3 | 23 |
| 11 | Newcastle UnitedNewcastle | 16 | 6 | 5 | 5 | 23 | 21 | 2 | 23 |
| 12 | Tottenham HotspurSpurs | 15 | 6 | 2 | 7 | 31 | 19 | 12 | 20 |
| 13 | Manchester UnitedMan Utd | 15 | 5 | 4 | 6 | 19 | 18 | 1 | 19 |
| 14 | West Ham UnitedWest Ham | 15 | 5 | 3 | 7 | 20 | 28 | -8 | 18 |
| 15 | Everton | 15 | 3 | 6 | 6 | 14 | 21 | -7 | 15 |
| 16 | Leicester CityLeicester | 16 | 3 | 5 | 8 | 21 | 34 | -13 | 14 |
| 17 | Crystal Palace | 15 | 2 | 7 | 6 | 14 | 20 | -6 | 13 |
| 18 | Ipswich TownIpswich | 16 | 2 | 6 | 8 | 16 | 28 | -12 | 12 |
| 19 | Wolverhampton WanderersWolves | 16 | 2 | 3 | 11 | 24 | 40 | -16 | 9 |
| 20 | Southampton | 15 | 1 | 2 | 12 | 11 | 31 | -20 | 5 |
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