Keinan Davis (hamstring) is sidelined along with Tom Heaton and Wesley, who both had surgery on season-ending knee injuries this week, as well as John McGinn (fractured ankle) and Jed Steer (Achilles).
Kevin De Bruyne has been given the all-clear for Manchester City trip to Villa Park.
The Belgium playmaker left the field after suffering a nasty blow in the closing stages of City's Carabao Cup victory at Manchester United in midweek.
Goalkeeper Ederson is likely to return after four games out due to a combination of rotation, illness and suspension. Defender Aymeric Laporte and winger Leroy Sane (both knee) are still out but both are back in training.
Aston Villa provisional squad: Nyland, Kalinic, Guilbert, Engels, Chester, Konsa, Mings, Taylor, Elmohamady, Luiz, Nakamba, Drinkwater, Targett, Grealish, Trezeguet, El Ghazi, Hourihane, Jota, Lansbury, Vassilev.
Man City provisional squad: Ederson, Bravo, Walker, Cancelo, Stones, Otamendi, Fernandinho, Garcia, Zinchenko, Mendy, Angelino, Gunodgan, Rodri, De Bruyne, D Silva, B Silva, Mahrez, Sterling, Foden, Aguero, Jesus.