The home side, who sit in fourth position, are without a win in two outings, while their opponents have lost ground in the title race with a surprise defeat against Brisbane Roar.
On the back of three successive wins, Macarthur would have had every confidence in defeating mid-table Brisbane Roar, who had failed to emerge victorious in their previous five games.
However, one of the surprise packages of the campaign were well beaten on home territory, their consolation goal coming in the final minutes through Lachlan Rose.
With four defeats having now been recorded from eight games, Ante Milicic must find a way to lift his players as they bid to stay in contention for top spot.
Still sitting just four points behind leaders Central Coast Mariners, there will be optimism that Macarthur can get back on track in the coming weeks.
Nevertheless, despite the goals of Matt Derbyshire, this team have now gone eight fixtures without scoring more than twice in a single game.
Like their opponents, Adelaide had put together a string of victories before seeing that run brought to a grinding halt with a defeat.
The 2-1 reverse to the Mariners was followed by a draw against Western Sydney Wanderers, a positive result for Adelaide given that they played the majority of the second half at a man disadvantage.
The Reds will have to show similar character on Wednesday having already succumbed to a 4-0 defeat to Macarthur as recently as February 12.
However, Adelaide have the second-best points-per-game ratio since that setback, claiming as many as 19 points from just eight fixtures.
Adelaide will be without Louis D'Arrigo after the young midfielder was sent off for two yellow cards during the last game.
Lachlan Rose is in line to earn a recall to the Macarthur side, potentially taking the place of Loic Puyo.
Adelaide United possible starting lineup:
Gauci; Strain, Elsey, Timotheou, Cavallo; Caletti, Juande; Halloran, Mauk, Goodwin; Juric
Macarthur possible starting lineup:
Federici; Golec, Milligan, Susnjar; Li.Rose, Benat, Genreau, Oar; La.Rose, Derbyshire, Hollman
We say: Adelaide United 1-1 Macarthur
With both teams having struggled at some point over the past two weeks, it would not come as a surprise if quality is lacking at the start of this contest. Nevertheless, we still expect a competitive encounter, one which could end in a low-scoring draw.