That result saw last season's runners-up slip down to 15th place in the table, with four points from their opening four games of the season.
Lyon have fared little better since the start of the campaign as one win and three defeats have put them in 16th place.
Hubert Fournier's team are on a three-match losing streak in the league, and another defeat on Friday would be likely to put genuine pressure on the manager.
Possible starting lineups
Lyon: Lopes; Jallet, Kone, Gonalons, Zeffane; Ferri, Tolisso, Mvuemba; N'Jie, Lacazette, Ghezzal
Monaco: Subasic; Fabinho, Raggi, Carvalho, Kurzawa; Moutinho, Toulalan, Kondogbia; Ferreira Carrasco, Berbatov, Germain
Sports Mole says: 1-2