Marco Streller's strike in the second half was enough to move the Swiss side into second place ahead of the Reds in Group B.
Sousa has no fresh injury concerns and he is expected to name the same XI that beat the Premier League outfit.
Despite losing their opening two matches to Liverpool and defending champions Real Madrid, Ludogorets have earned praise for their performances in the competition.
The Bulgarian outfit shocked Real by taking a seventh-minute lead against their more illustrious opponents two weeks ago, before Cristiano Ronaldo and Karim Benzema secured a 2-1 victory for the Spanish side.
Ludogorets will be looking for revenge against Wednesday's opponents, after Basel knocked them out of last season's Champions League qualification playoffs 6-2 on aggregate.
Possible starting lineups
Ludogorets: Stoyanov; Junior Caiçara, Moti, Aleksandrov, Minev; Dyakov, Dani Abalo, Andrianantenaina, M Aleksandrov; Bezjak, Marcelinho
Basel: Vaclik; Xhaka, Suchy, Schar, Safari; Frei, Elneny, Serey Die, Hamoudi; Streller, Embolo
Sports Mole says: 1-2