The Italian striker - a £16m signing from AC Milan - made a successful Reds debut in their 3-0 victory over Tottenham Hotspur before the international break.
Brendan Rodgers spent over £100m in the summer to make sure that the Merseysiders had the resources to cope with such injuries and could turn to either Adam Lallana or Lazar Markovic as Sturridge's replacement.
Lallana has been tipped to make his Liverpool bow this weekend, with a pre-season knee injury having prevented him from appearing for his new club since his £25m move from Southampton.
Rodgers also has one of the country's in-form players at his disposal in the shape of Raheem Sterling. The 19-year-old has helped Liverpool to six points from their opening three games and dazzled for England this week.
Villa midfielder Fabian Delph was another who impressed for the Three Lions as he made his competitive debut in the 2-0 Euro 2016 qualifying victory in Switzerland, and is believed to be close to signing a new contract with the Midlands outfit.
The Villans, who had been tipped as relegation candidates by many, have collected seven points from a possible nine so far, although they now face a run of consecutive games against last season's top five.
Their recent record against Liverpool should give them confidence, though. The Claret and Blues have lost only one of their last five top-flight trips to Anfield and won 3-1 there in December 2012.
Lambert must decide whether to stick with what has worked so far or make changes in midfield, where Manchester United loanee Tom Cleverley and Colombian international Carlos Sanchez await full debuts.
Sanchez may replace Charles N'Zogbia to provide Villa's backline with greater protection, with Kieran Richardson pushed out to the left to share the counter-attacking responsibility with Andreas Weimann.
Liverpool have defensive worries of their own, with Glen Johnson, Jon Flanagan and Martin Skrtel all sidelined, although Spanish duo Javi Manquillo and Alberto Moreno have already settled into their full-back roles.
The Reds have won eight out of their last nine home games and scored at least two goals in each of those victories.
Possible starting lineups
Liverpool: Mignolet; Manquillo, Lovren, Sakho, Moreno; Gerrard, Allen, Henderson; Lallana, Balotelli, Sterling
Villa: Guzan; Hutton, Vlaar, Senderos, Cissokho; Cleverley, Sanchez, Delph; Richardson, Weimann, Agbonlahor
Sports Mole says: 2-1