The Senegal international has served out a three-match domestic ban for colliding with Manchester City keeper Ederson earlier this month and is straight back in Jurgen Klopp's starting XI this evening.
Overall, Klopp makes three changes from the side that claimed a 3-2 victory at Leicester City in the Premier League on Saturday, with Philippe Coutinho dropping back into the midfield and Georginio Wijnaldum dropping down to the bench to make way for Mane, who starts alongside Roberto Firmino and Mohamed Salah in the frontline.
As expected, Loris Karius replaces Simon Mignolet between the sticks and Trent Alexander-Arnold comes in at right-back for Joe Gomez, who serves a one-game ban for seeing red in the 2-2 draw with Sevilla earlier in the month.
Joel Matip and Dejan Lovren continue their partnership in the heart of the back four, with Alberto Moreno on the left, while Emre Can and Jordan Henderson keep their places in the middle of the park alongside Coutinho.
For the hosts, Massimo Carrera has made three changes from the XI that started the side's 2-2 draw with Anzhi Makhachkala on Saturday, switching to a 5-4-1 for the visit of the Reds.
Quincy Promes continues to be absent for the hosts due to a calf injury.
Spartak Moscow: Rebrov; Eschenko, Kutepov, Tasci, Bocchetti, Dzhikiya; Samedov, Fernando, Pasalic, Popov; Adriano
Subs: Selikhov, Petkovic, Bakaev, Samsonov, Melgarejo, Davydov, Pedro Rocha
Liverpool: Karius; Alexander-Arnold, Lovren, Matip, Moreno; Henderson, Can, Coutinho; Salah, Mane, Firmino
Subs: Mignolet, Flanagan, Klavan, Milner, Wijnaldum, Oxlade-Chamberlain, Sturridge
Keep up with all of the action from Moscow tonight with Sports Mole's live text commentary here.