A daunting task now awaits 2018 runners-up Liverpool as they must overcome Bayern over two legs to progress.
Firmino knows Bayern well from his time in the Bundesliga, and with that in mind Sports Mole looks at his previous record against Die Roten.
The Brazil international came up against Bayern eight times during his four years with Hoffenheim, finding himself on the losing side six times.
Firmino's solitary strike against the reigning German champions came in a 3-3 draw at the Allianz Arena in March 2014, scoring the final goal of the match 15 minutes from time to earn his side a point.
That is one of only two occasions the 27-year-old has avoided defeat against Tuesday's opponents - the other being a goalless draw in October 2011.
Firmino has also never previously assisted a goal against Bayern, but that could all change in midweek as the Brazilian is now a far more dangerous player through the middle for Liverpool.