Ajax vs. Besiktas (Tuesday, 5.45pm)
The Dutch champions thrashed Os Leoes in the curtain-raiser, while their visitors fell to a defeat at the hands of group favourites Borussia Dortmund.
We say: Ajax 3-0 Besiktas
While their recent form sees Besiktas already arrive in Amsterdam as major underdogs, their extensive injury list only compounds their problems, and we see the Black Eagles being comfortably defeated.
Ajax have been in fine form this season, and should overrun a depleted Besiktas side on home turf, given their impressive attacking ranks.
Shakhtar vs. Inter Milan (Tuesday, 5.45pm)
We say: Shakhtar Donetsk 1-2 Inter Milan
PSG vs. Man City (Tuesday, 8.00pm)
The two sides renew hostilities after clashing in last season's semi-finals, where Pep Guardiola's men claimed a pair of victories to end the Parisiens' European dream for one more year.
We say: Paris Saint-Germain 1-2 Manchester City
PSG's perfect record in Ligue 1 does not exactly tell the full story given some of their under-par performances, while the potential loss of Messi and definite absence of Di Maria will certainly be felt in a clash of this magnitude.
Having had recent experience prevailing in battles with their French counterparts, Man City ought to feel confident about their chances of repeating the trick at the Parc des Princes, and we can see them doing just that by the narrowest of margins.
RB Leipzig vs. Brugge (Tuesday, 8.00pm)
The hosts were humbled 6-3 by Manchester City on matchday one, whereas their Belgian opponents managed to hold Paris Saint-Germain to a 1-1 draw on home soil.
We say: RB Leipzig 2-0 Club Brugge
Leipzig have their work cut out to breach a watertight Brugge defence six times, but such a crushing victory in the Bundesliga will have done wonders for the confidence in the hosts' camp.
Clement's side produced the goods against PSG in front of their own supporters and cannot be written off by any stretch, although we still expect Leipzig to keep their strong Champions League home run going with all three points on Tuesday.
Porto vs. Liverpool (Tuesday, 8.00pm)
We say: Porto 1-2 Liverpool
Porto have already proven themselves as a tough nut to crack both domestically and continentally this term, while their home record in the group stages speaks for itself, but some enforced defensive changes could harm them this week.
Klopp cannot afford to take any games in Group B lightly and must also factor in the impending visit of Man City, but we think a rotated Reds side will still have enough firepower to come away with all three points in a tightly-fought affair.
AC Milan vs. Atletico (Tuesday, 8.00pm)
AC Milan and Atletico Madrid will both go in search of their first wins of the 2021-22 Champions League during Tuesday's Group B battle at San Siro.
Stefano Pioli's side lost 3-2 to old rivals Liverpool in the opening matchweek, while Atletico failed to fire in a goalless draw with Porto.
We say: AC Milan 1-1 Atletico Madrid
Simeone must find a solution to Atletico's attacking woes soon lest they risk their La Liga title defence ending in tatters, but Liverpool have already proved that Milan's rearguard is far from impenetrable.
The Rossoneri will certainly have a hard time breaking down their visitors' own resilient backline, and we expect the two sides' search for a first European win of the season to continue following a hard-fought draw.
Dortmund vs. Sporting Lisbon (Tuesday, 8.00pm)
German giants Borussia Dortmund will look to make it two wins from two Champions League group stage games on Tuesday, when they welcome Portuguese champions Sporting Lisbon to Signal Iduna Park.
Marco Rose's side kicked off their campaign with a victory over Besiktas in the opening round of fixtures, while the visitors will be keen to bounce back from a thrashing at the hands of Ajax.
We say: Borussia Dortmund 3-1 Sporting Lisbon
Der BVB certainly excel going forward, and, even without a number of important players, they boast enough quality to condemn the Portuguese champions to another defeat.
If Haaland is deemed fit, he will hope to continue his eye-catching form on the continental stage with another rampant performance, and we would not look past Rose's men securing another high-scoring victory, especially if the Norwegian star leads the line.
Real Madrid vs. Sheriff Tiraspol (Tuesday, 8.00pm)
Real Madrid will be looking to make it back-to-back wins in Group D when they continue their 2021-22 Champions League campaign at home to Sheriff Tiraspol on Tuesday night.
Los Blancos recorded a 1-0 victory over Inter Milan in their section opener earlier this month, while Sheriff recorded an impressive 2-0 win over Shakhtar Donetsk, with the visitors currently top of the group.
We say: Real Madrid 2-0 Sheriff Tiraspol
Sheriff are more than capable of making this an uncomfortable evening for Real Madrid, with the Moldovan outfit impressing in their two-goal success over Shakhtar. That said, we are finding it difficult to predict anything other than Los Blancos win taking everything into consideration.