The former Manchester United midfielder is reportedly close to taking charge at the Championship club as he takes on the challenge of making a late push for the playoffs.
The home side enter the match 12th in the table, eight points off the playoffs, while Blackpool sit in 14th but just two points behind their opponents on Wednesday.
The reverse fixture at the beginning of the season ended in a 2-1 victory for Blackpool, but the Seasiders have also enjoyed recent success at Elland Road, running out 5-0 winners in November 2011.
Blackpool are expected to recall Tom Ince to their starting side, while on-loan Manchester City defender Reece Wabara is also pushing for an inclusion in defence having appeared from the bench last weekend.
Leeds: Kenny; Peltier, Lees, Pearce, Warnock; Varney, Green, Brown, Byram; Morison, McCormack
Blackpool: Gilks; Wabara, Crainey, Baptiste, Cathcart; Ince, Broadfort, Gomes; Phillips; Taylor-Fletcher, Derbyshire
Sports Mole says: 2-2