Southampton made it two wins in a row with a 3-1 victory over Fulham last time out to increase the gap between themselves and 15th-placed Burnley to four points, after Leeds won 4-0 against Burnley at Turf Moor on Saturday.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: Forster; Walker-Peters, Vestergaard, Stephens, Salisu; Tella, Ward-Prowse, Armstrong, Redmond; Adams, Ings
Sports Mole's predicted XI: Meslier; Ayling, Llorente, Struijk; Dallas, Phillips, Klich, Alioski; Raphinha, Bamford, Harrison
Watch the Sports Mole Football Shorts prediction for this game below: