The Italian giants have been knocked out of the Champions League and fallen further out of contention for a European spot next season during March, and a further setback could see them drop to 13th position in the table.
Three wins from their last four domestic fixtures have seen Lazio gain hold of seventh position in the standings.
Manager Edoardo Reja has seen the Rome-based outfit record two successive clean sheets, and he will be confident of a third shutout against Milan.
Reja could retain the same starting lineup that began last week's 2-0 win at Cagliari.
AC Milan: WLLLL
Possible starting lineups
Lazio: Marchetti; Biava, Konko, Radu, Novaretti; Ledesma, Biglia, Gonzalez; Lulic, Klose, Keita
AC Milan: Ameila; Bonera, Mexes, Abate, Emanuelson; De Jong, Essien, Montolivo, Poli, Kaka; Balotelli
Sports Mole says: 2-1