The 22-year-old missed his nation's 3-1 victory over Armenia on Friday evening with the flu.
However, he has now recovered and should partner Pablo Osvaldo in attack.
Veteran goalkeeper Gianluigi Buffon is expected to miss out with a thigh strain.
Meanwhile, Juventus's loanee frontman Nicklas Bendtner will feature as a lone striker for the visiting Danes.
Should he find the net, he will rise to 10th on Denmark's all-time goalscoring list.
Denmark are currently fifth in the group with two points from their opening two matches.
Possible starting lineups:
Italy: De Sanctis; Maggio, Barzagli, Chiellini, Criscito; Marchisio, De Rossi, Pirlo; Montolivo; Balotelli, Osvaldo
Denmark: Andersen; Jacobsen, Kjaer, Agger, Mtiliga; Kvist, Kristensen, Rommedahl, Eriksen, Krohn-Dehli; Bendtner
Sports Mole says: 2-1