The Azzurri's star striker Ciro Immobile will not play any part in October's fixtures due to injury, while Matteo Pessina and Rafael Toloi have also been forced to withdraw from the squad for the same reason.
With Immobile out of contention, Moise Kean ought to be given the opportunity to lead the line after bagging a brace in Italy's most recent game - a 5-0 thrashing of Lithuania in World Cup Qualifying.
Emerson is set to hold his place at left-back after Leonardo Spinazzola's devastating Achilles injury at Euro 2020, while Giovanni Di Lorenzo should get the nod over Davide Calabria on the opposite side.
At a combined age of 71, Giorgio Chiellini and Leonardo Bonucci continue to operate as Italy's first-choice defenders in front of Gianluigi Donnarumma, who has had to be patient for opportunities at Paris Saint-Germain since his arrival.
Italy possible starting lineup: Donnarumma; Di Lorenzo, Bonucci, Chiellini, Emerson; Barella, Jorginho, Verratti; Chiesa, Kean, Insigne