Both teams have already qualified for the semi-finals of the competition, with Prandelli now prepared to give his squad players a start.
"The important thing is to find the balance we lacked against Japan. At this moment we need fresh legs. Technical tweaks won't make a difference - we need physical sharpness," he told reporters at a press conference.
"The Confederations Cup is a wonderful and important competition, which means we should all have the same time and opportunities to prepare. Instead, many sides – including Italy – had to play a World Cup qualifier in the lead-up."
Italy were 4-3 winners over Japan last time out.