Both sides go into the match on the back of 1-0 wins on Saturday, with Ipswich squeezing past Charlton Athletic for their second straight away win, while Blackburn ended Leeds United's three-game winning streak at Ewood Park.
The pair are level on points in the table but Ipswich are two places better off in 11th because of their superior goal difference.
Williamson was replaced by Chris Taylor against Leeds and he took home the man of the match award, so should keep his place.
Gestede could join former Ipswich youngster Jordan Rhodes, who scored the winner when these two last met, in attack for the visitors.
Possible starting lineups
Ipswich: Gerken; Chambers, Berra, Smith, Cresswell; Anderson, Skuse, Tunnicliffe, Tabb; Murphy, McGoldrick
Blackburn: Kean; Kane, Dann, Hanley, Spurr; Taylor, Lowe, Williamson, King; Gestede, Rhodes
Sports Mole says: 2-1