Mick McCarthy's men reached the playoffs last season and their home form will be crucial if they are going to do so again.
Ipswich were left with a bitter taste in their mouths last weekend, when they threw away a two-goal lead in stoppage time at Brentford.
Ipswich hit back in the League Cup this week as they beat Stevenage 2-1, but McCarthy will put a greater emphasis on this game as he looks to mount a promotion challenge again.
McCarthy has kept the majority of his squad from last season, and keeping striker Darryl Murphy is seen a major coup. They have signed several players in this window so far, and have much more depth in their squad.
After the visit of Wednesday, Ipswich host Burnley before travelling North to play Preston North End.
Recent form: D
Recent form (all competitions): DW
Wednesday's fans can be forgiven for getting a little excited after their stellar start to the new campaign.
They backed that up with a thumping 4-1 win over Mansfield in the first round of the League Cup, so travel to Ipswich in good spirits.
Following their trip to Suffolk, Wednesday will face Reading at home before a Yorkshire derby with Leeds United.
Recent form: W
Recent form (all competitions): WW
Ipswich centre-back Christophe Berra could make his first league start since last season after returning from suspension.
The Scottish international was sent off against Norwich City in the playoffs last year, but played against Stevenage in midweek.
Jonathan Parr could return to the side at left-back.
Ipswich Town possible starting lineup:
Bialkowski; Chambers, Berra, Smith, Parr; Skuse, Bru, Fraser, Maitland-Niles; Sears, Murphy.
Sheffield Wednesday possible starting lineup:
Westwood; Hunt, Lees, Semedo, Helan; Matias, Lopez, McGugan, Hutchinson, Wallace; Nuhiu
Head To Head
Rather surprisingly for two old and historic clubs, this will be just their 46th meeting since the first in 1958.
Both sides have won 17 times while 11 others have been drawn, although Wednesday have not won in their last five attempts.
Hit play below to see what the Sports Mole Sofa had to say about this encounter:
We say: Ipswich Town 2-1 Sheffield Wednesday
Last season, Ipswich were outstanding at home as they collected 50 points, and it is clear that they feel comfortable in front of the Suffolk faithful.
Wednesday have had an encouraging start, but with a new manager and plenty of new signings it would be a surprise if they didn't have a topsy-turvy start. For those reasons, we are going for a 2-1 Ipswich win.