Palermo sit 18th in the league but two wins and two draws in their last four games have given them a real chance of survival.
Inter need to win to keep their hopes of Champions League qualification alive after they ended a two-match losing streak with victory over Parma last weekend.
Possible starting lineups
Palermo: Sorrentino; Von Bergen, Munoz, Aronica, Garcia; Morganella, Donati, Kurtic, Barreto; Miccoli, Boselli
Inter: Handanovic, Ranocchia, Jesus, Jonathan, Zanetti; Pereira, Kuzmanovic, Schelotto, Kovacic; Alvarez, Rocchi
Sports Mole says: 0-1