Antonio Conte's side dropped to second on Wednesday night due to Juventus's win over Sampdoria, but a win this weekend would see the Milan giants return to the summit on goal difference.
Inter have been excellent for much of the 2019-20 campaign but will enter this match on the back of a three-game winless run in all competitions.
Indeed, in addition to a 2-1 loss to Barcelona in their final Champions League group match, the 18-time Italian champions have drawn their last two in the league against Roma and Fiorentina.
Here, Sports Mole looks at how Inter could line up when they take to the field against the league's 19th-placed side.
Out: Alexis Sanchez (ankle), Stefano Sensi (abductor), Nicolo Barella (knee), Marcelo Brozovic (suspension), Lautaro Martinez (suspension)
Doubtful: Roberto Gagliardini (foot), Kwadwo Asamoah (knee), Antonio Candreva (back), Borja Valero (muscle)
Inter's absentee list heading into this weekend's clash with Genoa is vast.
Alexis Sanchez, Stefano Sensi and Nicolo Barella are all again out of contention, while Marcelo Brozovic and Lautaro Martinez, who have been vital for Inter this season, are both suspended.
Roberto Gagliardini and Kwadwo Asamoah are also still struggling, but Inter are hopeful that Antonio Candreva will overcome a back issue to feature.
Borja Valero, though, is being tipped to miss out in the middle of the park, meaning that there could be a start for 17-year-old Lucien Agoume, who made his Serie A debut in the draw with Fiorentina.
Valentino Lazaro and Matteo Politano are also expected to earn starts in the final third alongside Romelu Lukaku, meaning that Conte could switch his usual 3-5-2 formation to a 3-4-3 due to the number of absentees.