It has been a unique campaign for the Nerazzurri in many ways and one that could end on a high should they come out on top in Cologne later this week.
However, a failure to beat Europa League specialists Sevilla and questions may well be asked of Conte's future at San Siro, with him having also missed out on domestic silverware.
Ahead of the big clash at the RheinEnergieStadion, Sports Mole looks at how Inter's campaign has panned out up to this stage.
Throw the title-winning experience of Conte into the mix and it is fair to say that plenty was expected of the Nerazzurri this season.
Inter made an impressive start to their domestic campaign, too, by winning their opening six matches to take control at the top of the division.
In fact, Conte's men lost just one of their opening 23 matches - a 2-1 defeat to Juventus on October 6 - and led the way in early February.
However, successive defeats to Lazio and Juve allowed the latter to pounce and take hold of top spot, which they would not relinquish in the remaining months of the season.
Inter slipped as low as fourth at one point in the closing stages of the campaign following a run of two wins in six matches, though they did end strongly with three wins in a row.
A 2-0 victory over Atalanta BC on the final day of the Serie A season was enough to lift Inter into second place, just a point behind nine-in-a-row champions Juventus.
After overcoming Cagliari and Fiorentina in their first two domestic cup matches, Inter entered their semi-final tie with Napoli as the favourites of many to go all the way.
Fabian Ruiz scored the only goal of the first leg at San Siro, though, and Inter then had to wait four months for the return fixture as a result of the coronavirus pandemic.
Genaro Gattuso's men went on to beat Juventus in the final, with Conte admitting that it was an opportunity lost for his side to win some silverware.
Inter started the season in the Champions League but failed to progress through a group containing Barcelona and Borussia Dortmund.
A 1-1 home draw with Slavia Prague in their opening Group F clash left Inter with a huge mountain to climb and they ultimately failed to recover, finishing third in the standings.
After further strengthening in January, Conte's men were instantly installed as favourites to win the Europa League and have so far won five games from five in the knockouts.
The Nerazzurri won both legs against Ludogorets Razgrad, before battling to a 2-0 win over Getafe in a one-legged last-16 tie in the reformatted knockout stages.
Then came a 2-1 win over Bayer Leverkusen, early strikes from Barella and Lukaku setting up a semi-final with Shakhtar Donetsk.
The Ukrainians impressed en route to the final four but struggled to put up much of a fight against Conte's rampant charges, with Lukaku registering twice in a thumping 5-0 win.