Just two points separated the teams last season and both clubs will be hopeful of avoiding a poor run of form so early in the campaign as they look to stay clear of the relegation zone.
Getafe needed three managers to avoid relegation last season, but after Cosmin Contra, Quique Flores and Pablo Franco all moved on, Fran Escriba is in the spotlight now as he looks to guide the club through a far more comfortable campaign.
With 14th and 19th being separated by just five points, the Getafe supporters will be fully aware how fortunate they were to survive a return to the second tier of Spanish football but the club strengthened the squad in the summer by signing the likes of Moi Gomez and Bernard Mensah.
However, it was a frustrating start to the new campaign as they slipped to a 1-0 defeat against Espanyol after the hosts broke the deadlock with a free kick from Salva Sevilla in just the third minute.
Despite matching Espanyol for long spells, Escriba will certainly be disappointed with the lack of clear chances his side created and the loss was made even worse when Santiago Vergini picked up a red card late on.
A return to action in front of their home fans brings its own pressure, but Escriba will be optimistic that his side will find their clinical touch as they look to get points on the board before a tricky trip to Athletic Bilbao after the international break.
Recent league form: L
If Getafe were happy to avoid relegation from last season, Granada's supporters may have only just finished their sigh of relief after a dramatic finish to their campaign.
Granada spent 20 successive matchdays in the bottom three before finally securing their La Liga status with a four-match unbeaten run which ended with a goalless draw against Atletico Madrid on the final day.
Much like Getafe, managerial changes were a regular occurrence from the club's hierarchy before they appointed Jose Ramon Sandoval, who guided the team to their success over the final four games to earn hero status with the fans.
The target remains the same for Sandoval as he looks to steer his team to another year in the top flight of Spanish football, but the former Rayo Vallecano and Sporting Gijon boss will certainly be disappointed with their start to the new season.
Granada were the only side to concede three goals on the opening weekend as they suffered a 3-1 loss at home to Eibar, and the performance against a side with similar aims is sure to come as a concern for Sandoval.
Villarreal, Real Madrid, Real Sociedad and Valencia await Granada after the international break, and the club's supporters will already be concerned about an extended losing run if their side fail to take something from their trip to Getafe on Sunday.
Recent league form: L
Despite having very few chances to make an impact against Espanyol last week, Alvaro Vazquez should be trusted to lead the line for Getafe once again, with Pablo Sarabia in line to provide the main support to the lone striker.
Getafe possible starting lineup:
Guaita, Alexis, Velazquez, Suarez, Vigaray, J. Rodriguez, Lacen, Leon, Gomez, Sarabia, Vazquez
Granada possible starting lineup:
Fernandez, Mainz, Babin, Foulquier, Lopes, Marquez, Perez, Ibanez, Success, Rochina, El-Arabi
Head To Head
These two sides have met eight times in La Liga, with Granada claiming three victories and Getafe earning two wins in a stretch of games which has seen neither team win by more than two goals.
Sandoval took charge of Granada for the first time against Getafe in the first week of May and celebrated a 2-1 victory to start the run which ensured they remained in La Liga for another season.
We say: Getafe 2-0 Granada
Getafe will be keen to prove that last week's loss was the result of a sloppy start, rather than a sign that this season could be another frustrating campaign for the club's fans. Granada appeared vulnerable in defence in their opener. The hosts should capitalise to pick up the win.