The Germans are currently at the top of Group D with six points thanks to two wins from their opening two games of the competition.
However, their form in the Bundesliga has been poor this season, with five defeats out of eight leaving them in 14th place in the table.
Meanwhile, hosts Galatasaray head into the match at the bottom of the group after taking just one point from a possible six.
Despite their disappointing start in Europe, Cesare Prandelli's side have won three of their last four games in all competitions and will be eager to improve on that record in midweek.
Erik Durm is likely to miss out for the visitors after suffering an injury during the warm-up before Saturday's defeat to FC Koln. Ilkay Gundogan, Marco Reus and Henrikh Mkhitaryan are all expected to feature after their recent returns from injury.
Possible starting lineups
Galatasaray: Muslera; Chedjou, Kaya, Camdal, Sari; Melo, Dzemaili, Adin, Inan; Sneijder; Yilmaz
Dortmund: Weidenfeller; Piszczek, Papastathopoulos, Hummels, Grosskreutz; Kehl, Gundogan; Mkhitaryan, Kagawa, Reus; Immobile
Sports Mole says: 1-2