The Cottagers failed to enhance their survival chances with a third win in a row last weekend, when Tottenham Hotspur won an end-to-end London derby 3-1.
However, it was always going to be their home matches which decided Fulham's fate and the visit of poor travellers Hull gives them the ideal chance to make more significant progress in their great escape.
The Whites are currently two points adrift of safety and play first in this round of fixtures, which see 17th-place Norwich City visit Manchester United on Saturday evening and Cardiff City and Sunderland, the two teams either side of them in the table, face each other at the Stadium of Light on Sunday.
Hull's position looks much healthier than Fulham's, but a six-point gap between them and the drop zone is not yet enough for the FA Cup finalists to celebrate a second successive top-flight campaign.
However, form suggests that the Tigers may have to wait one more week before clinching survival as they have suffered 11 away defeats this season, with only Fulham and Norwich City having lost more.
Matty Fryatt was his half-time replacement and could be promoted to a starting berth, although Bruce may consider reverting to five at the back after conceding a total of six goals in their last two games.
There are as many as six players facing late fitness tests, although there are good signs on the fitness of Sascha Riether, Kieran Richardson and Mahamadou Diarra, who could replace William Kvist in midfield.
Scott Parker is another who is battling with injury, but is expected to fight through the pain to play alongside top goalscorer Steve Sidwell, who will try to lend support to lone forward Hugo Rodallega.
Possible starting lineups
Fulham: Stockdale; Hangeland, Heitinga, Amorebieta; Riether, Diarra, Sidwell, Parker, Riise; Holtby; Rodallega
Hull: Harper; Elmohamady, Davies, Chester, Figueroa, Rosenior; Meyler, Huddlestone, Livermore, Boyd; Jelavic
Sports Mole says: 1-1