Les Bleus' 26-man squad includes the likes of uncapped defender Jules Kounde and recalled talisman Karim Benzema - back after a five-year absence - but the injured Anthony Martial and Ferland Mendy will play no part at this summer's tournament.
Kounde could very well earn his first cap for the national team this week as Deschamps looks to avoid injuries to key players, while Mike Maignan - fresh off the back of a Ligue 1 title triumph with Lille - could start in goal.
N'Golo Kante and Paul Pogba will be midfield shoo-ins when the Euros rolls around, but Adrien Rabiot and Moussa Sissoko could feature against Wales, especially with Corentin Tolisso's injury problems a concern for Deschamps.
Kylian Mbappe may not be risked, but Olivier Giroud, Wissam Ben Yedder and Benzema are all vying for the opportunity to impress, and the latter may be given the nod after settling his differences with Deschamps.
France possible starting lineup: Maignan; Dubois, Kounde, Lenglet, Digne; Rabiot, Sissoko; Dembele, Griezmann, Lemar; Benzema