Steve McClaren's side travel to the Keepmoat Stadium knowing that if they fail to win and Burnley defeat Blackpool, their hopes of automatic promotion are gone.
McClaren is likely to go with the same side that saw off Huddersfield Town last time out, with John Eustace possibly set for a return in midfield.
Donny, meanwhile, have lost their last three games and go into Friday's game just three points above the bottom three.
Derby have won the last three matches between these two, with the December reverse fixture a 3-1 victory for the Rams.
Possible starting lineups
Donny: Johnstone; Quinn, Tamas, Meite, Husband; Cotterill, Keegan, Furman, Coppinger; Brown, Sharp
Derby: Grant; Wisdom, Keogh, Buxton, Forsyth; Thorne, Bryson, Hughes; Bamford, Martin, Russell
Sports Mole says: 0-2