Nuno keeps faith with the XI that delivered a 1-0 win over promotion favourites Middlesbrough at Molineux last weekend, with youngster Bright Enobakhare starting up front alongside Diogo Jota and Leo Bonatini, who grabbed the winner against Boro.
Matt Doherty, Romain Saiss, Ruben Neves and Barry Douglas make up the midfield in a 3-4-3 formation, with Roderick Miranda, skipper Conor Coady and Willy Boly in the backline ahead of John Ruddy in goal.
Ivan Cavaleiro is back in the matchday squad after serving out his suspension and takes his place on the bench alongside Nouha Dicko, who claimed the winner against Yeovil Town in the EFL Cup in midweek.
Derby County: Carson; Wisdom, Keogh, Davies, Forsyth; Butterfield, Huddlestone, Johnson; Russell, Martin, Weimann
Subs: Mitchell, Bryson, Anya, Baird, Pearce, Bennett, Nugent
Wolverhampton Wanderers: Ruddy; Miranda, Coady, Boly; Doherty, Saiss, Neves, Douglas; Enobakhare, Bonatini, Jota
Subs: Norris, Bennett, Batth, Cavaleiro, Dicko, Price, Ronan