The Sky Blues were beaten 2-1 by Nottingham Forest on Tuesday to get dragged back into the Championship relegation mix, while the Hornets lost by the same scoreline against Queens Park Rangers on Monday to slip to fifth.
It was only a third home defeat of the season for Mark Robins's side and their first since October, and they now sit four points above the relegation zone in 18th position.
It is representative of what a difference one round of matches can make because if Coventry had beaten Forest, they would have moved up to 14th and sat in mid-table serenity.
However, a defeat to a side just underneath them in the table, as well as wins for Sheffield Wednesday and Rotherham United in midweek, now has the Sky Blues looking nervously over their shoulder again.
Robins's side have a tricky period ahead too as they face four of the top five in their next five matches, starting with Watford's trip to the Midlands.
Coventry have only won two of their last 13 meetings with the Hornets and lost 3-2 in the reverse fixture in November.
It was a crazy second half at Vicarage Road as Watford went from winning 1-0 to losing 2-1 and then drawing 2-2 in the space of four minutes, before Ismaila Sarr's late penalty secured the victory.
The Hertfordshire side have, typically, changed managers since then and current boss Xisco Munoz has indicated that he will switch up his tactics ahead of the weekend; this comes off the back of a pair of uninspiring results, with the defeat to QPR following a dull 0-0 draw with Millwall.
Defender William Troost-Ekong has said that the clash with Coventry could be "the moment that's going to change our season" as the Hornets must improve their away form if they want to compete for the automatic promotion spots; they are currently four points behind second place Brentford, who have a game in hand.
Watford have only won three out of 16 games on the road this season, while only Luton Town have scored fewer away goals. At the other end of the pitch, however, only Birmingham City have conceded fewer away goals.
Coventry City Championship form: LWLWDL
Coventry City form (all competitions): WLLWDL
Watford Championship form: LWWWDL
Watford form (all competitions): LWWWDL
Coventry centre-back Kyle McFadzean is available again after he tested positive for coronavirus and had to self-isolate for 10 days, but goalkeeper Ben Wilson remains absent following his positive test.
McFadzean's return will likely mean that Robins goes with a back three, particularly as midfielder Ben Sheaf is a doubt after coming off at half time against Nottingham Forest with a hamstring problem.
Meanwhile, Julien Da Costa could come in for his first Championship start at right wing-back after impressing as a substitute in midweek.
With Xisco expected to change tack at St Andrew's, Will Hughes could move into a central position, allowing Ken Sema to start on the left hand side.
Strikers Stipe Perica and Isaac Success have been back in training in the last few days but are still a week or so away from featuring, while new signing Dan Gosling is unlikely to play as he works on his match fitness.
Coventry City possible starting lineup:
Marosi; Ostigard, Hyam, McFadzean; Da Costa, Hamer, James, McCallum; O'Hare, Biamou, Gyokeres
Watford possible starting lineup:
Bachmann; Femenia, Sierralta, Troost-Ekong, Masina; Cleverley, Chalobah; Sarr, Hughes, Sema; Deeney
We say: Coventry City 1-2 Watford
Xisco will hope that a change in system breathes new life into his players as on their day the Watford squad should have far too much quality for a team like Coventry. However, the Sky Blues have held their own in the Championship this season and will not be beaten easily.