The England striker was expected to be on the sidelines for an extended period of time due to an ankle ligament injury suffered against Bournemouth earlier this month.
However, Kane's seemingly quicker-than-anticipated recovery from the issue has seen him claim a spot on the Spurs bench for the big game in West London.
Pochettino has made three changes elsewhere, with Eric Dier, Mousa Dembele and Dele Alli - who makes his 100th top-flight appearance - returning after the 3-0 FA Cup win over Swansea City last time out.
As for Chelsea, first-choice goalkeeper Thibaut Courtois is again absent from the squad, having failed to recover from a hamstring injury in time for the Easter Sunday encounter.
Chelsea: Caballero; Azpilicueta, Christensen, Rudiger; Moses, Kante, Fabregas, Alonso; Willian, Hazard; Morata
Subs: Eduardo, Cahill, Emerson, Drinkwater, Bakayoko, Hudson-Odoi, Giroud
Tottenham Hotspur: Lloris; Trippier, Sanchez, Vertonghen, Davies; Dier, Dembele; Lamela, Eriksen, Alli; Son
Subs: Vorm, Aurier, Rose, Wanyama, Sissoko, Lucas, Kane
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