Frank Lampard's side played out a goalless draw with Sevilla in their Group E opener last week and were also held to a stalemate by Manchester United on Saturday.
The Blues have now won just one of their last six outings across all competitions, but will be favourites against Krasnodar for what is only the Russian outfit's second ever match in the Champions League proper.
Here Sports Mole rounds up all of Chelsea's latest injury and suspension news ahead of the contest.
Status: Major doubt
Type of injury: Shoulder
Possible return date: October 28 (vs. Krasnodar)
Kepa Arrizabalaga has lost his first-team place at Chelsea and also picked up a shoulder injury last week, meaning that he would likely be unable to feature on Wednesday even if Lampard wanted him to.
Type of injury: Knee
Possible return date: Unknown
Billy Gilmour could return after the next international break in November, having stepped up his recovery from a knee injury.
CHELSEA'S SUSPENSION LIST
Return date: November 4 (vs. Rennes)
Marcos Alonso continues to serve a ban carried over from last season, when he was shown a straight red card against Bayern Munich.