Lukasz Zaluska is in goal for Celtic after regular number one Fraser Forster was sidelined with a neck injury.
Australian midfielder Tomas Rogic is awaiting a work permit and James Forrest and Paddy McCourt are injured.
Danny Wilson makes his debut for Hearts after joining on loan from Liverpool, but captain Marius Zaliukas and Ryan Stevenson are both suspended.
Scott Robinson also misses out with a knock for the Jambos.
Celtic: Zaluska, Matthews, Lustig, Mulgrew, Izaguirre, Commons, Brown, Wanyama, Ledley, Samaras, Hooper.
Hearts: MacDonald, Barr, Webster, Wilson, McHattie, Holt, McGowan, Taouil, Driver, Paterson, Sutton.