Chris Hughton makes just the one change from the side that beat Fulham at the Amex last time out as the Seagulls look to replace Newcastle United at the top of the Championship table.
Knockaert instead takes a place on the bench this afternoon after a couple of out-of-sorts performances following the death of his father a few weeks ago.
Glenn Murray and Sam Baldock, who claimed a goal apiece against the Cottagers, continue their partnership up front, with Skalak joining Dale Stephens, Steve Sidwell and Jamie Murphy in the middle of the park.
For the hosts, Neil Warnock makes three changes from the XI that started the defeat at Aston Villa as he looks to lift the side out of the relegation zone.
Cardiff City: Amos; Connolly, Bennett, Morrison, Bamba; Harris, Gunnarsson, Whittingham, Ralls; Gounongbe, Hoilett
Subs: Wilson, Manga, Noone, Pilkington, Richardson, Zohore, Chamakh
Brighton & Hove Albion: Stockdale; Bruno, Duffy, Dunk, Bong; Skalak, Stephens, Sidwell, Murphy; Murray, Baldock
Subs: Maenpaa, Pocognoli, Goldson, Norwood, March, Knockaert, Hemed