Despite taking a two-goal lead against Norwich City on Saturday, the Bluebirds slipped to a 4-2 defeat which left them 15th in the table.
Mats Moller Daehli was not risked at the weekend after picking up an injury while on duty for Norway, but is expected to be fit for Tuesday's match.
Meanwhile, Tuesday's visitors have been in mixed form this season, winning three and losing three of their six outings in the Championship so far this campaign.
Middlesbrough needed an injury-time winner to beat Huddersfield Town at the weekend and are 10th in the table heading into this fixture.
The sides did not meet last season as Cardiff were in the Premier League, but Middlesbrough were 2-1 winners last time they played in 2013.
Possible starting lineups
Cardiff: Marshall; Brayford, Gabbidon, Manga, Morrison, Fabio; Daehli, Whittingham, Gunnarsson; Macheda, Jones
Middlesbrough: Konstantopoulos; Friend, Ayala, Gibson, Perez; Adomah, Clayton, Vossen, Leadbitter, Tomlin; Martinez
Sports Mole says: 2-1