Meanwhile, SonderjyskE have their sights on moving closer to mid-table after a three-match winless streak before football was suspended due to the coronavirus pandemic.
While challenging for top spot is out of the equation, Brondby will now be focused on cementing their place in the Championship round at the end of the season.
Holding a four-point advantage over seventh-placed Randers, Niels Frederiksen will back his players to achieve their target over the final two games, despite the change of circumstances going forward.
Brondby went into the enforced break having recorded eight points from their five fixtures in 2020, a considerable improvement considering that they lost their final three games of the previous year.
However, Drengene fra Vestegnen would have been disappointed with their last performance, twice letting slip a lead at third-placed Nordsjaelland before eventually recording a 2-2 draw.
That proved to be the difference between Brondby heading into the break in fifth rather than third, and Frederiksen will be eager to bounce back from that frustrating result in what is, on paper, the perfect match after a prolonged break.
From SonderjyskE's perspective, they will feel that they can only benefit from a time of reflection after picking up just four points from five matches this year.
Their sole success came at home to Hobro, a team which has only registered two wins all season, and it leaves Glen Riddersholm with plenty of work ahead of him over the coming weeks.
Regardless of their form in the remaining fixtures, SonderjyskE will feature in the relegation round, but it is imperative that they finish as high in the standings as possible.
Realistically, eighth place can still be achieved with victories over Brondby and Silkeborg - results which may make all of the difference when it comes to survival in the top flight.
Brondby form: LDWLWD
SonderjyskE form: WLWLLD
Head To Head
Brondby have dominated this head-to-head, recording 21 wins and seven draws from the last 39 contests between the sides.
However, SonderjyskE have emerged victorious in three of the most recent four encounters, including in the last two fixtures to be played at the Brondby Stadium in all competitions.
They also got the better of Tuesday's hosts when the teams clashed at Sydbank Park in September.
We say: Brondby 2-1 SonderjyskE
With three months having passed since their last fixtures, the form book goes out of the window. However, despite the lack of crowd, we have to back Brondby to prevail on familiar territory, perhaps by a closer scoreline than many would have anticipated before the suspension.