The Seasiders beat Sheffield Wednesday 2-0 on Tuesday night and Appleton could decide to keep the same team that began the match at Hillsborough.
Thomas Ince continued his impressive form against the Owls with a goal that takes his tally to eight goals in 13 league games this season.
The Trotters continue to languish in the bottom half of the Championship table but their improvement under Freedman could encourage the Scot to keep faith with the side that drew with fifth-placed Leicester.
Bolton Wanderers: LWDLWD
Possible starting lineups:
Blackpool: Gilks; Crainey, Eardley, Baptiste, Cathcart; Basham, M.Phillips, Grandin, Sylvestre, Ince; Taylor-Fletcher
Bolton Wanderers: Bogdan; Mills, Knight, Warnock, Ricketts; Eagles, Andrews, M Davies, Pratley, Lee; K Davies
Sports Mole says: 1-1