Goalkeeper Thibaut Courtois is the only member of the lineup who started against the Three Lions in the Red Devils' final group match.
Japan, meanwhile, have made six changes from the side which lost 1-0 to Poland last time out.
Shinji Okazaki of Leicester City, who has picked up an ankle injury, is among the players to drop out.
Belgium: Courtois; Alderweireld, Kompany, Vertonghen; Witsel, Meunier, De Bruyne, Carrasco; Mertens, E. Hazard; Lukaku
Subs: Vermaelen, Dembele, Fellaini, Mignolet, Chadli, Casteels, Boyata, Batshuayi, Hazard, Dendoncker, Januzaj, Tielemans
Japan: Kawashima; H. Sakai, Yoshida, Shoji, Nagatomo; Hasebe, Shibasaki; Haraguchi, Kagawa, Inui; Osako
Subs: Honda, Okazaki, Usami, Higashiguchi, Endo, Yamaguchi, Makino, Oshima, Nakamura, Ueda, Sakai, Muto
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