The hosts are two points above their opponents ahead of this winner-takes-all tie, with top spot and a place in next year's finals at stake for both countries.
Belgium ensured that lightning did not strike twice for England after losing to the Three Lions at Wembley last month, with Roberto Martinez's men running out 2-0 winners despite being on the back foot for large periods of the tie.
Youri Tielemans struck first for Belgium, who doubled their lead through a sweetly-struck Dries Mertens free kick, and the Red Devils' rearguard kept England at bay throughout the 90 minutes to leave Belgium needing just a point to advance to the finals.
October's defeat at Wembley remains the only time that Belgium have failed to pick up all three points in the 2020-21 Nations League, with Martinez's men winning four of their five group stage matches and chalking up 12 goals along the way - the most scored by any team in all four leagues.
With Mertens, Kevin De Bruyne and Romelu Lukaku running the show for Belgium, it is no surprise that the number-one ranked side in the world have accumulated an impressive number of goals in their bid to reach the Nations League finals, but the group is not done and dusted just yet.
Avoid defeat and the Red Devils will progress, but Belgium will cede their place in the final four to Denmark should their midweek opponents defy the odds and prevail on matchday six.
Denmark's penultimate match of the 2020-21 Nations League also saw them pick up a much-needed three points, although the Scandinavians' route to victory against Iceland was not a simple one by any means.
Christian Eriksen broke the deadlock from the spot before an 85th-minute goal from Vidar Kjartansson looked to have rescued a draw for Iceland, who would have secured their first-ever point in the Nations League before Eriksen struck once again from 12 yards in the dying moments.
It was a cruel blow for Iceland, but a crucial win for Denmark, who are still in with a shout of qualifying for the Nations League finals before their trip to Leuven, in which nothing less than a victory will do for the visitors.
Kasper Hjulmand's men certainly know all about wins, though, as Denmark have triumphed in their last five games in all competitions, and only Portugal and Italy (2) have conceded fewer goals than Denmark (3) in League A.
Belgium and Denmark locked horns in the first matchday of the 2020-21 Nations League, and it was the world's number one ranked side who took the spoils in that one thanks to goals from Jason Denayer and Mertens.
Belgium Nations League form: WWLWW
Belgium form (all competitions): WDLWWW
Denmark Nations League form: LDWWW
Denmark form (all competitions): DWWWWW
Otherwise, Belgium's lineup is set to remain the same, although Leander Dendoncker could potentially return from injury in time to challenge Praet for a spot in the middle of the park.
Meanwhile, the injuries keep piling up all over the shop as Denmark number one Kasper Schmeichel was forced off following a heavy collision, although Hjulmand affirmed that the Leicester City man was not knocked unconscious.
Concussion protocols state that a player should not take to the pitch until six days have passed, but a decision over Schmeichel's involvement will ultimately be made by Denmark, with Frederik Ronnow on standby and ready to deputise if necessary.
Belgium possible starting lineup:
Courtois; Alderweireld, Denayer, Vertonghen; Foket, Praet, Tielemans, Hazard; Mertens, De Bruyne; Lukaku
Denmark possible starting lineup:
Ronnow; Christensen, Kjaer, Vestergaard; Wass, Delaney, Hojbjerg, Larsen; Eriksen; Braithwaite, Poulsen
We say: Belgium 2-1 Denmark
Wednesday's game is poised to be a fascinating winner-takes-all battle between two sides enjoying strong spells of form as of late. Belgium may be tempted to err on the side of caution, as all they need to do is stop Denmark winning to qualify, but Martinez will want to see his side stamp their authority on the group with a victory and we expect the Red Devils to secure a spot in the finals with a narrow triumph.