A 1-0 victory over Manchester City in the Champions League on Wednesday has given the Bundesliga champions a big confidence boost, and they head into the weekend knowing that they could claim top spot with a win.
There will be very few backing against Pep Guardiola's men as they take on the league's bottom side looking for a third win from four games.
It's been a frustrating start to the new season for Hamburger, who have managed to earn just one point from their opening three fixtures, and they begin a new era on Saturday following Mirko Slomka's sacking, with Josef Zinnbauer taking charge of the team for the first time.
However, the mood in the dressing room could be improved if, as expected, Rafael van der Vaart makes his return from injury.
There are still a few questions to be answered about who will be available for Bayern, with doubts remaining over Franck Ribery, who sat out the win over Man City.
Arjen Robben is likely to be ready to start the match after coming off the bench on Wednesday night, but Thiago Alcantara is still working his way back to full fitness following a long battle with a knee problem.
Hamburger SV: Drobny, Diekmeier, Djourou, Cleber, Ostrzolek, Behrami, Holtby, Stieber, Muller, Van der Vaart, Lasogga
Bayern Munich: Neuer, Rafinha, Benatia, Boateng, Bernat, Lahm, Alonso, Alaba, Robben, Muller, Lewandowski
Possible starting lineups
Hamburger SV: DLL
Bayern Munich: WDW
Sports Mole says: 0-3