The Catalan giants thrashed Saturday's opponents 7-0 when the two teams last met, and go into the game unbeaten in the league during the current campaign.
Paco Jemez's side are in erratic form, lying in mid-table on a run of just one win in six.
Rayo Vallecano: LLLWL
Rayo Vallecano: Andrade; Tito, Casado, Labaka, Galvez; Carlos, Fuego, Abu, Baptistao; Piti, Dominguez
Barcelona: Valdes; Alves, Song, Mascherano, Alba; Fabregas, Xavi, Iniesta, Adriano; Messi, Pedro
Sports Mole says: 0-3